Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors

Kinase inhibitors are effective cancer therapies, but tumors frequently develop resistance. Current strategies to circumvent resistance target the same or parallel pathways. We report here that targeting a completely different process, autophagy, can overcome multiple BRAF inhibitor resistance mecha...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Mulcahy Levy, Jean M, Zahedi, Shadi, Griesinger, Andrea M, Morin, Andrew, Davies, Kurtis D, Aisner, Dara L, Kleinschmidt-DeMasters, BK, Fitzwalter, Brent E, Goodall, Megan L, Thorburn, Jacqueline, Amani, Vladimir, Donson, Andrew M, Birks, Diane K, Mirsky, David M, Hankinson, Todd C, Handler, Michael H, Green, Adam L, Vibhakar, Rajeev, Foreman, Nicholas K, Thorburn, Andrew
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2017
Assuntos:
Cancer Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241115/
https://ncbi.nlm.nih.gov/pubmed/28094001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19671
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