Intracranial Injection of Dengue Virus Induces Interferon Stimulated Genes and CD8(+) T Cell Infiltration by Sphingosine Kinase 1 Independent Pathways

We have previously reported that the absence of sphingosine kinase 1 (SK1) affects both dengue virus (DENV) infection and innate immune responses in vitro. Here we aimed to define SK1-dependancy of DENV-induced disease and the associated innate responses in vivo. The lack of a reliable mouse model w...

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Bibliographic Details
Published in:PLoS One
Main Authors: Al-Shujairi, Wisam H., Clarke, Jennifer N., Davies, Lorena T., Alsharifi, Mohammed, Pitson, Stuart M., Carr, Jillian M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240945/
https://ncbi.nlm.nih.gov/pubmed/28095439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169814
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