Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology

N-methyl-D-aspartate receptors (NMDARs), ligand-gated ionotropic glutamate receptors, play key roles in normal brain development and various neurological disorders. Here we use standing variation data from the human population to assess which protein domains within NMDAR GluN1, GluN2A and GluN2B sub...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Ogden, Kevin K., Chen, Wenjuan, Swanger, Sharon A., McDaniel, Miranda J., Fan, Linlin Z., Hu, Chun, Tankovic, Anel, Kusumoto, Hirofumi, Kosobucki, Gabrielle J., Schulien, Anthony J., Su, Zhuocheng, Pecha, Joseph, Bhattacharya, Subhrajit, Petrovski, Slavé, Cohen, Adam E., Aizenman, Elias, Traynelis, Stephen F., Yuan, Hongjie
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240934/
https://ncbi.nlm.nih.gov/pubmed/28095420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006536
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