IDH1 deficiency attenuates gluconeogenesis in mouse liver by impairing amino acid utilization

Although the enzymatic activity of isocitrate dehydrogenase 1 (IDH1) was defined decades ago, its functions in vivo are not yet fully understood. Cytosolic IDH1 converts isocitrate to α-ketoglutarate (α-KG), a key metabolite regulating nitrogen homeostasis in catabolic pathways. It was thought that...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Ye, Jing, Gu, Yu, Zhang, Feng, Zhao, Yuanlin, Yuan, Yuan, Hao, Zhenyue, Sheng, Yi, Li, Wanda Y., Wakeham, Andrew, Cairns, Rob A., Mak, Tak W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240724/
https://ncbi.nlm.nih.gov/pubmed/28011762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618605114
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