Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response

Protein AMPylation is a conserved posttranslational modification with emerging roles in endoplasmic reticulum homeostasis. However, the range of substrates and cell biological consequences of AMPylation remain poorly defined. We expressed human and Caenorhabditis elegans AMPylation enzymes—huntingti...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Truttmann, Matthias C., Zheng, Xu, Hanke, Leo, Damon, Jadyn R., Grootveld, Monique, Krakowiak, Joanna, Pincus, David, Ploegh, Hidde L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2017
Ämnen:
PNAS Plus
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240723/
https://ncbi.nlm.nih.gov/pubmed/28031489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619234114
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