Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response

Protein AMPylation is a conserved posttranslational modification with emerging roles in endoplasmic reticulum homeostasis. However, the range of substrates and cell biological consequences of AMPylation remain poorly defined. We expressed human and Caenorhabditis elegans AMPylation enzymes—huntingti...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Truttmann, Matthias C., Zheng, Xu, Hanke, Leo, Damon, Jadyn R., Grootveld, Monique, Krakowiak, Joanna, Pincus, David, Ploegh, Hidde L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2017
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240723/
https://ncbi.nlm.nih.gov/pubmed/28031489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619234114
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