Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response

Protein AMPylation is a conserved posttranslational modification with emerging roles in endoplasmic reticulum homeostasis. However, the range of substrates and cell biological consequences of AMPylation remain poorly defined. We expressed human and Caenorhabditis elegans AMPylation enzymes—huntingti...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Truttmann, Matthias C., Zheng, Xu, Hanke, Leo, Damon, Jadyn R., Grootveld, Monique, Krakowiak, Joanna, Pincus, David, Ploegh, Hidde L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240723/
https://ncbi.nlm.nih.gov/pubmed/28031489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619234114
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