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Large-scale heterochromatin remodeling linked to overreplication-associated DNA damage

Previously, we have shown that loss of the histone 3 lysine 27 (H3K27) monomethyltransferases ARABIDOPSIS TRITHORAX-RELATED 5 (ATXR5) and ATXR6 (ATXR6) results in the overreplication of heterochromatin. Here we show that the overreplication results in DNA damage and extensive chromocenter remodeling...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Feng, Wei, Hale, Christopher J., Over, Ryan S., Cokus, Shawn J., Jacobsen, Steven E., Michaels, Scott D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240675/
https://ncbi.nlm.nih.gov/pubmed/28028228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619774114
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