Broad epitope coverage of a human in vitro antibody library

Successful discovery of therapeutic antibodies hinges on the identification of appropriate affinity binders targeting a diversity of molecular epitopes presented by the antigen. Antibody campaigns that yield such broad “epitope coverage” increase the likelihood of identifying candidates with the des...

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Pubblicato in:MAbs
Autori principali: Sivasubramanian, Arvind, Estep, Patricia, Lynaugh, Heather, Yu, Yao, Miles, Adam, Eckman, Josh, Schutz, Kevin, Piffath, Crystal, Boland, Nadthakarn, Niles, Rebecca Hurley, Durand, Stéphanie, Boland, Todd, Vásquez, Maximiliano, Xu, Yingda, Abdiche, Yasmina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2016
Soggetti:
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240653/
https://ncbi.nlm.nih.gov/pubmed/27748644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1246096
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