Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice

The t(8;21)(q22;q22) translocation, present in 10-15% of acute myeloid leukemia (AML) cases, generates the AML1/ETO fusion protein. To study the role of AML1/ETO in the pathogenesis of AML, we used the Ly6A locus that encodes the well characterized hematopoietic stem cell marker, Sca1, to target exp...

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Bibliographic Details
Main Authors: Fenske, Timothy S., Pengue, Gina, Mathews, Vikram, Hanson, Piia T., Hamm, Sarah E., Riaz, Noor, Graubert, Timothy A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC524043/
https://ncbi.nlm.nih.gov/pubmed/15477599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400751101
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