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Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice
The t(8;21)(q22;q22) translocation, present in 10-15% of acute myeloid leukemia (AML) cases, generates the AML1/ETO fusion protein. To study the role of AML1/ETO in the pathogenesis of AML, we used the Ly6A locus that encodes the well characterized hematopoietic stem cell marker, Sca1, to target exp...
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| Päätekijät: | , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2004
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC524043/ https://ncbi.nlm.nih.gov/pubmed/15477599 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400751101 |
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