Selective Ablation of GIRK Channels in Dopamine Neurons Alters Behavioral Effects of Cocaine in Mice

The increase in dopamine (DA) neurotransmission stimulated by in vivo cocaine exposure is tempered by G protein-dependent inhibitory feedback mechanisms in DA neurons of the ventral tegmental area (VTA). G protein-gated inwardly rectifying K(+) (GIRK/Kir3) channels mediate the direct inhibitory effe...

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Publicat a:Neuropsychopharmacology
Autors principals: McCall, Nora M, Kotecki, Lydia, Dominguez-Lopez, Sergio, Marron Fernandez de Velasco, Ezequiel, Carlblom, Nicholas, Sharpe, Amanda L, Beckstead, Michael J, Wickman, Kevin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240170/
https://ncbi.nlm.nih.gov/pubmed/27468917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2016.138
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