GIRK Channels Modulate Opioid-Induced Motor Activity in a Cell Type- and Subunit-Dependent Manner

G-protein-gated inwardly rectifying K(+) (GIRK/Kir3) channel activation underlies key physiological effects of opioids, including analgesia and dependence. GIRK channel activation has also been implicated in the opioid-induced inhibition of midbrain GABA neurons and consequent disinhibition of dopam...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Kotecki, Lydia, Hearing, Matthew, McCall, Nora M., Marron Fernandez de Velasco, Ezequiel, Pravetoni, Marco, Arora, Devinder, Victoria, Nicole C., Munoz, Michaelanne B., Xia, Zhilian, Slesinger, Paul A., Weaver, C. David, Wickman, Kevin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420781/
https://ncbi.nlm.nih.gov/pubmed/25948263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5051-14.2015
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