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Negative regulation of type I IFN signaling by phosphorylation of STAT2 on T387
The transcription factor ISGF3, comprised of IRF9 and tyrosine‐phosphorylated STATs 1 and 2, transmits the signal from the type I interferon receptor to the genome. We have discovered a novel phosphorylation of STAT2 on T387 that negatively regulates this response. In most untreated cell types, the...
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| 出版年: | EMBO J |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5239994/ https://ncbi.nlm.nih.gov/pubmed/27852626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201694834 |
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