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HER2-HER3 dimer quantification by FLIM-FRET predicts breast cancer metastatic relapse independently of HER2 IHC status

Overexpression of HER2 is an important prognostic marker, and the only predictive biomarker of response to HER2-targeted therapies in invasive breast cancer. HER2-HER3 dimer has been shown to drive proliferation and tumor progression, and targeting of this dimer with pertuzumab alongside chemotherap...

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書誌詳細
出版年:Oncotarget
主要な著者: Weitsman, Gregory, Barber, Paul R., Nguyen, Lan K., Lawler, Katherine, Patel, Gargi, Woodman, Natalie, Kelleher, Muireann T., Pinder, Sarah E., Rowley, Mark, Ellis, Paul A., Purushotham, Anand D., Coolen, Anthonius C., Kholodenko, Boris N., Vojnovic, Borivoj, Gillett, Cheryl, Ng, Tony
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5239455/
https://ncbi.nlm.nih.gov/pubmed/27618787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9963
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