Induction of Vascular GTP-Cyclohydrolase I and Endogenous Tetrahydrobiopterin Synthesis Protect Against Inflammation-Induced Endothelial Dysfunction in Human Atherosclerosis

BACKGROUND: The endothelial nitric oxide synthase cofactor tetrahydrobiopterin (BH4) is essential for maintenance of enzymatic function. We hypothesized that induction of BH4 synthesis might be an endothelial defense mechanism against inflammation in vascular disease states. METHODS AND RESULTS: In...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Circulation
Prif Awduron: Antoniades, Charalambos, Cunnington, Colin, Antonopoulos, Alexis, Neville, Matt, Margaritis, Marios, Demosthenous, Michael, Bendall, Jennifer, Hale, Ashley, Cerrato, Ruha, Tousoulis, Dimitris, Bakogiannis, Constantinos, Marinou, Kyriakoula, Toutouza, Marina, Vlachopoulos, Charalambos, Leeson, Paul, Stefanadis, Christodoulos, Karpe, Fredrik, Channon, Keith M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238937/
https://ncbi.nlm.nih.gov/pubmed/21969008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.029272
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