Induction of Vascular GTP-Cyclohydrolase I and Endogenous Tetrahydrobiopterin Synthesis Protect Against Inflammation-Induced Endothelial Dysfunction in Human Atherosclerosis

BACKGROUND: The endothelial nitric oxide synthase cofactor tetrahydrobiopterin (BH4) is essential for maintenance of enzymatic function. We hypothesized that induction of BH4 synthesis might be an endothelial defense mechanism against inflammation in vascular disease states. METHODS AND RESULTS: In...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Circulation
Κύριοι συγγραφείς: Antoniades, Charalambos, Cunnington, Colin, Antonopoulos, Alexis, Neville, Matt, Margaritis, Marios, Demosthenous, Michael, Bendall, Jennifer, Hale, Ashley, Cerrato, Ruha, Tousoulis, Dimitris, Bakogiannis, Constantinos, Marinou, Kyriakoula, Toutouza, Marina, Vlachopoulos, Charalambos, Leeson, Paul, Stefanadis, Christodoulos, Karpe, Fredrik, Channon, Keith M.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2011
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238937/
https://ncbi.nlm.nih.gov/pubmed/21969008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.029272
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