Induction of Vascular GTP-Cyclohydrolase I and Endogenous Tetrahydrobiopterin Synthesis Protect Against Inflammation-Induced Endothelial Dysfunction in Human Atherosclerosis

BACKGROUND: The endothelial nitric oxide synthase cofactor tetrahydrobiopterin (BH4) is essential for maintenance of enzymatic function. We hypothesized that induction of BH4 synthesis might be an endothelial defense mechanism against inflammation in vascular disease states. METHODS AND RESULTS: In...

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Publicado no:Circulation
Main Authors: Antoniades, Charalambos, Cunnington, Colin, Antonopoulos, Alexis, Neville, Matt, Margaritis, Marios, Demosthenous, Michael, Bendall, Jennifer, Hale, Ashley, Cerrato, Ruha, Tousoulis, Dimitris, Bakogiannis, Constantinos, Marinou, Kyriakoula, Toutouza, Marina, Vlachopoulos, Charalambos, Leeson, Paul, Stefanadis, Christodoulos, Karpe, Fredrik, Channon, Keith M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238937/
https://ncbi.nlm.nih.gov/pubmed/21969008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.029272
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