Systemic and Vascular Oxidation Limits the Efficacy of Oral Tetrahydrobiopterin Treatment in Patients With Coronary Artery Disease

BACKGROUND: The endothelial nitric oxide synthase cofactor tetrahydrobiopterin (BH4) plays a pivotal role in maintaining endothelial function in experimental vascular disease models and in humans. Augmentation of endogenous BH4 levels by oral BH4 treatment has been proposed as a potential therapeuti...

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Publicado no:Circulation
Main Authors: Cunnington, Colin, Van Assche, Tim, Shirodaria, Cheerag, Kylintireas, Ilias, Lindsay, Alistair C., Lee, Justin M., Antoniades, Charalambos, Margaritis, Marios, Lee, Regent, Cerrato, Ruha, Crabtree, Mark J., Francis, Jane M., Sayeed, Rana, Ratnatunga, Chandi, Pillai, Ravi, Choudhury, Robin P., Neubauer, Stefan, Channon, Keith M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238935/
https://ncbi.nlm.nih.gov/pubmed/22315282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.038919
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