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CTCF-mediated topological boundaries during development foster appropriate gene regulation
The genome is organized into repeating topologically associated domains (TADs), each of which is spatially isolated from its neighbor by poorly understood boundary elements thought to be conserved across cell types. Here, we show that deletion of CTCF (CCCTC-binding factor)-binding sites at TAD and...
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| 發表在: | Genes Dev |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Cold Spring Harbor Laboratory Press
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5238725/ https://ncbi.nlm.nih.gov/pubmed/28087711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.288324.116 |
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