CTCF-mediated topological boundaries during development foster appropriate gene regulation

The genome is organized into repeating topologically associated domains (TADs), each of which is spatially isolated from its neighbor by poorly understood boundary elements thought to be conserved across cell types. Here, we show that deletion of CTCF (CCCTC-binding factor)-binding sites at TAD and...

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Detaylı Bibliyografya
Yayımlandı:Genes Dev
Asıl Yazarlar: Narendra, Varun, Bulajić, Milica, Dekker, Job, Mazzoni, Esteban O., Reinberg, Danny
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2016
Konular:
Research Communication
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238725/
https://ncbi.nlm.nih.gov/pubmed/28087711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.288324.116
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