CTCF-mediated topological boundaries during development foster appropriate gene regulation

The genome is organized into repeating topologically associated domains (TADs), each of which is spatially isolated from its neighbor by poorly understood boundary elements thought to be conserved across cell types. Here, we show that deletion of CTCF (CCCTC-binding factor)-binding sites at TAD and...

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Библиографические подробности
Опубликовано в: :Genes Dev
Главные авторы: Narendra, Varun, Bulajić, Milica, Dekker, Job, Mazzoni, Esteban O., Reinberg, Danny
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2016
Предметы:
Research Communication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238725/
https://ncbi.nlm.nih.gov/pubmed/28087711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.288324.116
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