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New syntheses of (±)-tashiromine and (±)-epitashiromine via enaminone intermediates

The syntheses of the naturally occurring indolizidine alkaloid (±)-tashiromine and its unnatural epimer (±)-epitashiromine are demonstrated through the use of enaminone chemistry. The impact of various electron-withdrawing substituents at the C-8 position of the indolizidine core on the preparation...

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Publicado en:Beilstein J Org Chem
Main Authors: Riley, Darren L, Michael, Joseph P, de Koning, Charles B
Formato: Artigo
Idioma:Inglês
Publicado: Beilstein-Institut 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238587/
https://ncbi.nlm.nih.gov/pubmed/28144330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.12.256
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