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Guidance for the utility of linear models in meta-analysis of genetic association studies of binary phenotypes

Linear mixed models are increasingly used for the analysis of genome-wide association studies (GWAS) of binary phenotypes because they can efficiently and robustly account for population stratification and relatedness through inclusion of random effects for a genetic relationship matrix. However, th...

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Detalhes bibliográficos
Publicado no:Eur J Hum Genet
Main Authors: Cook, James P, Mahajan, Anubha, Morris, Andrew P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5237383/
https://ncbi.nlm.nih.gov/pubmed/27848946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2016.150
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