A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations

PURPOSE: Predicting target site drug concentration in the brain is of key importance for the successful development of drugs acting on the central nervous system. We propose a generic mathematical model to describe the pharmacokinetics in brain compartments, and apply this model to predict human bra...

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Détails bibliographiques
Publié dans:Pharm Res
Auteurs principaux: Yamamoto, Yumi, Välitalo, Pyry A., van den Berg, Dirk-Jan, Hartman, Robin, van den Brink, Willem, Wong, Yin Cheong, Huntjens, Dymphy R., Proost, Johannes H., Vermeulen, An, Krauwinkel, Walter, Bakshi, Suruchi, Aranzana-Climent, Vincent, Marchand, Sandrine, Dahyot-Fizelier, Claire, Couet, William, Danhof, Meindert, van Hasselt, Johan G. C., de Lange, Elizabeth C. M.
Format: Artigo
Langue:Inglês
Publié: Springer US 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5236087/
https://ncbi.nlm.nih.gov/pubmed/27864744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-016-2065-3
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