Leukotriene A4 hydrolase: determination of the three zinc-binding ligands by site-directed mutagenesis and zinc analysis.

Three mutants of recombinant mouse leukotriene A4 (LTA4) hydrolase (3.3.2.6) were produced by site-directed mutagenesis on cDNA. The codons corresponding to His-295, His-299, or Glu-318 were replaced by codons encoding tyrosine, tyrosine, and glutamine, respectively. The mutated cDNAs were expressed...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Medina, J F, Wetterholm, A, Rådmark, O, Shapiro, R, Haeggström, J Z, Vallee, B L, Samuelsson, B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52353/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1881903/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.17.7620
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