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Molecular triangulation: Bridging linkage and molecular-network information for identifying candidate genes in Alzheimer's disease

A major challenge in human genetics is identifying the molecular basis of common heritable disorders. In contrast to rare single-gene diseases, multifactorial disorders are thought to arise from the combined effect of multiple gene variants, such that any single variant may have only a modest effect...

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Detalhes bibliográficos
Main Authors: Krauthammer, Michael, Kaufmann, Charles A., Gilliam, T. Conrad, Rzhetsky, Andrey
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC523448/
https://ncbi.nlm.nih.gov/pubmed/15471992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404315101
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