Enhanced neuroinflammation mediated by DNA methylation of the glucocorticoid receptor triggers cognitive dysfunction after sevoflurane anesthesia in adult rats subjected to maternal separation during the neonatal period

BACKGROUND: Mounting evidence indicates that children who experience abuse and neglect are prone to chronic diseases and premature mortality later in life. One mechanistic hypothesis for this phenomenon is that early life adversity alters the expression or functioning of the glucocorticoid receptor...

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Опубликовано в: :J Neuroinflammation
Главные авторы: Zhu, Yangzi, Wang, Yu, Yao, Rui, Hao, Ting, Cao, Junli, Huang, He, Wang, Liwei, Wu, Yuqing
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2017
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5234142/
https://ncbi.nlm.nih.gov/pubmed/28086911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0782-5
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