Enhanced neuroinflammation mediated by DNA methylation of the glucocorticoid receptor triggers cognitive dysfunction after sevoflurane anesthesia in adult rats subjected to maternal separation during the neonatal period

BACKGROUND: Mounting evidence indicates that children who experience abuse and neglect are prone to chronic diseases and premature mortality later in life. One mechanistic hypothesis for this phenomenon is that early life adversity alters the expression or functioning of the glucocorticoid receptor...

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Published in:J Neuroinflammation
Main Authors: Zhu, Yangzi, Wang, Yu, Yao, Rui, Hao, Ting, Cao, Junli, Huang, He, Wang, Liwei, Wu, Yuqing
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5234142/
https://ncbi.nlm.nih.gov/pubmed/28086911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0782-5
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