Brain Maturation in Neonatal Rodents is Impeded by Sevoflurane Anesthesia

BACKGROUND: A wealth of data shows neuronal demise after general anesthesia in the very young rodent brain. Here we apply proton magnetic resonance spectroscopy (1HMRS), testing the hypothesis that neurotoxic exposure during peak synaptogenesis can be tracked via changes in neuronal metabolites. MET...

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發表在:Anesthesiology
Main Authors: Makaryus, Rany, Lee, Hedok, Feng, Tian, Park, June-Hee, Nedergaard, Maiken, Jacob, Zvi, Enikolopov, Grigori, Benveniste, Helene
格式: Artigo
語言:Inglês
出版: 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543401/
https://ncbi.nlm.nih.gov/pubmed/26181336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000000762
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