Brain Maturation in Neonatal Rodents is Impeded by Sevoflurane Anesthesia

BACKGROUND: A wealth of data shows neuronal demise after general anesthesia in the very young rodent brain. Here we apply proton magnetic resonance spectroscopy (1HMRS), testing the hypothesis that neurotoxic exposure during peak synaptogenesis can be tracked via changes in neuronal metabolites. MET...

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Detalhes bibliográficos
Publicado no:Anesthesiology
Main Authors: Makaryus, Rany, Lee, Hedok, Feng, Tian, Park, June-Hee, Nedergaard, Maiken, Jacob, Zvi, Enikolopov, Grigori, Benveniste, Helene
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543401/
https://ncbi.nlm.nih.gov/pubmed/26181336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000000762
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