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Evolutionary Transition toward Defective RNAs That Are Infectious by Complementation

Passage of foot-and-mouth disease virus (FMDV) in cell culture resulted in the generation of defective RNAs that were infectious by complementation. Deletions (of nucleotides 417, 999, and 1017) mapped in the L proteinase and capsid protein-coding regions. Cell killing followed two-hit kinetics, def...

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Detalhes bibliográficos
Main Authors: García-Arriaza, Juan, Manrubia, Susanna C., Toja, Miguel, Domingo, Esteban, Escarmís, Cristina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC523252/
https://ncbi.nlm.nih.gov/pubmed/15479809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.21.11678-11685.2004
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