The Amino Terminus of Epstein-Barr Virus (EBV) Nuclear Antigen 1 Contains AT Hooks That Facilitate the Replication and Partitioning of Latent EBV Genomes by Tethering Them to Cellular Chromosomes

During latency, Epstein-Barr virus (EBV) is stably maintained as a circular plasmid that is replicated once per cell cycle and partitioned at mitosis. Both these processes require a single viral protein, EBV nuclear antigen 1 (EBNA1), which binds two clusters of cognate binding sites within the late...

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Bibliografiske detaljer
Main Authors: Sears, John, Ujihara, Maki, Wong, Samantha, Ott, Christopher, Middeldorp, Jaap, Aiyar, Ashok
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC523237/
https://ncbi.nlm.nih.gov/pubmed/15479791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.21.11487-11505.2004
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