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Metaphase Chromosome Tethering Is Necessary for the DNA Synthesis and Maintenance of oriP Plasmids but Is Insufficient for Transcription Activation by Epstein-Barr Nuclear Antigen 1

Epstein-Barr Virus (EBV) infects resting B cells, within which it establishes latency as a stable, circular episome with only two EBV components, the cis element oriP and the latently expressed protein EBNA1. It is believed that EBNA1's ability to tether oriP episomes to metaphase chromosomes i...

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Autori principali: Sears, John, Kolman, John, Wahl, Geoffrey M., Aiyar, Ashok
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC229350/
https://ncbi.nlm.nih.gov/pubmed/14557661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.21.11767-11780.2003
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