The carbohydrate domain of calicheamicin gamma I1 determines its sequence specificity for DNA cleavage.

We have investigated the DNA cleaving properties of calicheamicinone, the synthetic core aglycone of calicheamicin gamma I1, a natural product with extremely potent antitumor activity. Our experiments have shown that the synthetic analog binds and cleaves DNA, albeit without any sequence selectivity...

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Detaylı Bibliyografya
Asıl Yazarlar: Drak, J, Iwasawa, N, Danishefsky, S, Crothers, D M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1991
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC52320/
https://ncbi.nlm.nih.gov/pubmed/1881884
Etiketler: Etiketle
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