Glu-192----Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin.
In serine proteases, residue 192, three residues prior to the active site Ser-195, plays an important role in determining substrate specificity. In trypsin (EC 3.4.21.4) and most trypsin-like enzymes with relatively broad specificity, this position is occupied by Gln. In thrombin (EC 3.4.21.5), an e...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1991
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52297/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1678522/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.16.7371 |
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