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Critical role for the Val/Gly86 HLA-DR beta dimorphism in autoantigen presentation to human T cells.

Helper T lymphocytes recognize fragments of foreign (or self) antigens in the peptide-binding clefts of major histocompatibility complex class II molecules; their activation is a crucial step in the induction of many immune and autoimmune responses. While studying the latter, we raised a T-cell line...

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Guardat en:
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Ong, B, Willcox, N, Wordsworth, P, Beeson, D, Vincent, A, Altmann, D, Lanchbury, J S, Harcourt, G C, Bell, J I, Newsom-Davis, J
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1991
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52291/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1714600/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.16.7343
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