Genome-wide lethality screen identifies new PI4,5P(2) effectors that regulate the actin cytoskeleton

To further understand the roles played by the essential phosphoinositide PI4,5P(2), we have used a synthetic lethal analysis, which systematically combined the mss4(ts) mutation, partially defective in PI4P 5-kinase activity, with each of approximately 4700 deletion mutations. This genomic screening...

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Bibliographic Details
Published in:EMBO J
Main Authors: Audhya, Anjon, Loewith, Robbie, Parsons, Ainslie B, Gao, Lu, Tabuchi, Mitsuaki, Zhou, Huilin, Boone, Charles, Hall, Michael N, Emr, Scott D
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2004
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Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC522789/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15372071/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600384
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