Reverse Pathway Genetic Approach Identifies Epistasis in Autism Spectrum Disorders

Although gene-gene interaction, or epistasis, plays a large role in complex traits in model organisms, genome-wide by genome-wide searches for two-way interaction have limited power in human studies. We thus used knowledge of a biological pathway in order to identify a contribution of epistasis to a...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Mitra, Ileena, Lavillaureix, Alinoë, Yeh, Erika, Traglia, Michela, Tsang, Kathryn, Bearden, Carrie E., Rauen, Katherine A., Weiss, Lauren A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226683/
https://ncbi.nlm.nih.gov/pubmed/28076348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006516
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