Parkin deficiency exacerbate ethanol-induced dopaminergic neurodegeneration by P38 pathway dependent inhibition of autophagy and mitochondrial function

Parkinson's disease (PD) is a neurodegenerative disease characterized by selective degeneration of dopaminergic neurons in the substantia nigra. Parkin (which encoded by Park2), an E3 ubiquitin ligase, is the most frequently mutated gene that has casually been linked to autosomal recessive earl...

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Gepubliceerd in:Redox Biol
Hoofdauteurs: Hwang, Chul Ju, Kim, Young Eun, Son, Dong Ju, Park, Mi Hee, Choi, Dong-Young, Park, Pil-Hoon, Hellström, Mats, Han, Sang-Bae, Oh, Ki-Wan, Park, Eun Kyung, Hong, Jin Tae
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2016
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226672/
https://ncbi.nlm.nih.gov/pubmed/28086194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2016.12.008
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