Myotubularin-related protein 7 inhibits insulin signaling in colorectal cancer

Phosphoinositide (PIP) phosphatases such as myotubularins (MTMs) inhibit growth factor receptor signaling. However, the function of myotubularin-related protein 7 (MTMR7) in cancer is unknown. We show that MTMR7 protein was down-regulated with increasing tumor grade (G), size (T) and stage (UICC) in...

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Udgivet i:Oncotarget
Main Authors: Weidner, Philip, Söhn, Michaela, Gutting, Tobias, Friedrich, Teresa, Gaiser, Timo, Magdeburg, Julia, Kienle, Peter, Ruh, Hermelindis, Hopf, Carsten, Behrens, Hans-Michael, Röcken, Christoph, Hanoch, Tamar, Seger, Rony, Ebert, Matthias P.A., Burgermeister, Elke
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226598/
https://ncbi.nlm.nih.gov/pubmed/27409167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10466
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