Targeting synthetic lethality between the SRC kinase and the EPHB6 receptor may benefit cancer treatment

Application of tumor genome sequencing has identified numerous loss-of-function alterations in cancer cells. While these alterations are difficult to target using direct interventions, they may be attacked with the help of the synthetic lethality (SL) approach. In this approach, inhibition of one ge...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Paul, James M., Toosi, Behzad, Vizeacoumar, Frederick S., Bhanumathy, Kalpana Kalyanasundaram, Li, Yue, Gerger, Courtney, Zawily, Amr El, Freywald, Tanya, Anderson, Deborah H., Mousseau, Darrell, Kanthan, Rani, Zhang, Zhaolei, Vizeacoumar, Franco J., Freywald, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226566/
https://ncbi.nlm.nih.gov/pubmed/27418135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10569
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