Targeting of RET oncogene by naphthalene diimide-mediated gene promoter G-quadruplex stabilization exerts anti-tumor activity in oncogene-addicted human medullary thyroid cancer

Medullary thyroid cancer (MTC) relies on the aberrant activation of RET proto-oncogene. Though targeted approaches (i.e., tyrosine kinase inhibitors) are available, the absence of complete responses and the onset of resistance mechanisms indicate the need for novel therapeutic interventions. Due to...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Lopergolo, Alessia, Perrone, Rosalba, Tortoreto, Monica, Doria, Filippo, Beretta, Giovanni L., Zuco, Valentina, Freccero, Mauro, Borrello, Maria Grazia, Lanzi, Cinzia, Richter, Sara N., Zaffaroni, Nadia, Folini, Marco
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226536/
https://ncbi.nlm.nih.gov/pubmed/27351133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10105
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