Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease

Previous studies showed that YAP1 is over-expressed in hepatocellular carcinoma (HCC). Here we observed higher expression of Yap1/Ctgf axis in dysplastic nodules and HCC chemically-induced in F344 rats, genetically susceptible to hepatocarcinogenesis, than in lesions induced in resistant BN rats. In...

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Udgivet i:Oncotarget
Main Authors: Simile, Maria M., Latte, Gavinella, Demartis, Maria I., Brozzetti, Stefania, Calvisi, Diego F., Porcu, Alberto, Feo, Claudio F., Seddaiu, Maria A., Daino, Lucia, Berasain, Carmen, Tomasi, Maria L., Avila, Matias A., Feo, Francesco, Pascale, Rosa M.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226501/
https://ncbi.nlm.nih.gov/pubmed/27359056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10246
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