Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease

Previous studies showed that YAP1 is over-expressed in hepatocellular carcinoma (HCC). Here we observed higher expression of Yap1/Ctgf axis in dysplastic nodules and HCC chemically-induced in F344 rats, genetically susceptible to hepatocarcinogenesis, than in lesions induced in resistant BN rats. In...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Simile, Maria M., Latte, Gavinella, Demartis, Maria I., Brozzetti, Stefania, Calvisi, Diego F., Porcu, Alberto, Feo, Claudio F., Seddaiu, Maria A., Daino, Lucia, Berasain, Carmen, Tomasi, Maria L., Avila, Matias A., Feo, Francesco, Pascale, Rosa M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226501/
https://ncbi.nlm.nih.gov/pubmed/27359056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10246
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