Detection of Mismatch Repair Deficiency and Microsatellite Instability in Colorectal Adenocarcinoma by Targeted Next-Generation Sequencing

Mismatch repair protein deficiency (MMR-D) and high microsatellite instability (MSI-H) are features of Lynch syndrome–associated colorectal carcinomas and have implications in clinical management. We evaluate the ability of a targeted next-generation sequencing panel to detect MMR-D and MSI-H based...

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Detalhes bibliográficos
Publicado no:J Mol Diagn
Main Authors: Nowak, Jonathan A., Yurgelun, Matthew B., Bruce, Jacqueline L., Rojas-Rudilla, Vanesa, Hall, Dimity L., Shivdasani, Priyanka, Garcia, Elizabeth P., Agoston, Agoston T., Srivastava, Amitabh, Ogino, Shuji, Kuo, Frank C., Lindeman, Neal I., Dong, Fei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2017
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225299/
https://ncbi.nlm.nih.gov/pubmed/27863258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmoldx.2016.07.010
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