Microsatellite Instability and DNA Mismatch Repair Protein Deficiency in Lynch Syndrome Colorectal Polyps

Colorectal cancers associated with Lynch syndrome (LS) are characterized by deficient DNA mismatch repair (MMR) function. Our aim was to evaluate the prevalence of microsatellite instability (MSI) and loss of MMR protein expression in LS-associated polyps. Sixty two colorectal polyps – 37 adenomas (...

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Detalhes bibliográficos
Main Authors: Yurgelun, Matthew B., Goel, Ajay, Hornick, Jason L., Sen, Ananda, Turgeon, D. Kim, Ruffin, Mack T., Marcon, Norman E., Baron, John A., Bresalier, Robert S., Syngal, Sapna, Brenner, Dean E., Boland, C. Richard, Stoffel, Elena M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461594/
https://ncbi.nlm.nih.gov/pubmed/22262812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-11-0519
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