First-in-Human Evaluation of the Safety and Immunogenicity of an Intranasally Administered Replication-Competent Sendai Virus–Vectored HIV Type 1 Gag Vaccine: Induction of Potent T-Cell or Antibody Responses in Prime-Boost Regimens

Background. We report the first-in-human safety and immunogenicity assessment of a prototype intranasally administered, replication-competent Sendai virus (SeV)–vectored, human immunodeficiency virus type 1 (HIV-1) vaccine. Methods. Sixty-five HIV-1–uninfected adults in Kenya, Rwanda, and the United...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Nyombayire, Julien, Anzala, Omu, Gazzard, Brian, Karita, Etienne, Bergin, Philip, Hayes, Peter, Kopycinski, Jakub, Omosa-Manyonyi, Gloria, Jackson, Akil, Bizimana, Jean, Farah, Bashir, Sayeed, Eddy, Parks, Christopher L., Inoue, Makoto, Hironaka, Takashi, Hara, Hiroto, Shu, Tsugumine, Matano, Tetsuro, Dally, Len, Barin, Burc, Park, Harriet, Gilmour, Jill, Lombardo, Angela, Excler, Jean-Louis, Fast, Patricia, Laufer, Dagna S., Cox, Josephine H.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225252/
https://ncbi.nlm.nih.gov/pubmed/28077588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiw500
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