LJM716 in Japanese patients with head and neck squamous cell carcinoma or HER2-overexpressing breast or gastric cancer

PURPOSE: Human epidermal growth factor receptor 3 (HER3) has been identified as an important component of many receptor tyrosine kinase-driven cancers. LJM716 is a human IgG monoclonal antibody that binds HER3, trapping it in an inactive conformation. In this study, a phase I dose escalation was per...

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Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Main Authors: Takahashi, Shunji, Kobayashi, Takayuki, Tomomatsu, Junichi, Ito, Yoshinori, Oda, Hisanobu, Kajitani, Tatsuhiro, Kakizume, Tomoyuki, Tajima, Takeshi, Takeuchi, Hiromi, Maacke, Heiko, Esaki, Taito
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225197/
https://ncbi.nlm.nih.gov/pubmed/27942917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-016-3214-4
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