Epidermal growth factor signaling protects from cholestatic liver injury and fibrosis

ABSTRACT: We have demonstrated that the signal transducer and activator of transcription 3 (STAT3) protects from cholestatic liver injury. Specific ablation of STAT3 in hepatocytes and cholangiocytes (STAT3(∆hc)) aggravated liver damage and fibrosis in the Mdr2(−/−) (multidrug resistance 2) mouse mo...

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Bibliografiske detaljer
Udgivet i:J Mol Med (Berl)
Main Authors: Svinka, Jasmin, Pflügler, Sandra, Mair, Markus, Marschall, Hanns-Ulrich, Hengstler, Jan G., Stiedl, Patricia, Poli, Valeria, Casanova, Emilio, Timelthaler, Gerald, Sibilia, Maria, Eferl, Robert
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2016
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225179/
https://ncbi.nlm.nih.gov/pubmed/27568040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-016-1462-8
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