Variant adiponutrin confers genetic protection against cholestatic itch

Lysophosphatidic acid (LPA) mediates cholestatic pruritus. Recently the enzyme PNPLA3, expressed in liver and skin, was demonstrated to metabolise LPA. Here we assess the association of the PNPLA3 variant p.Ile148Met, known to be associated with (non-)alcoholic fatty liver disease (NAFLD) in genome-...

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Hlavní autoři: Krawczyk, Marcin, Milkiewicz, Malgorzata, Marschall, Hanns-Ulrich, Bartz, Clemens, Grünhage, Frank, Wunsch, Ewa, Milkiewicz, Piotr, Lammert, Frank
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190538/
https://ncbi.nlm.nih.gov/pubmed/25297933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06374
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