Variant adiponutrin confers genetic protection against cholestatic itch

Lysophosphatidic acid (LPA) mediates cholestatic pruritus. Recently the enzyme PNPLA3, expressed in liver and skin, was demonstrated to metabolise LPA. Here we assess the association of the PNPLA3 variant p.Ile148Met, known to be associated with (non-)alcoholic fatty liver disease (NAFLD) in genome-...

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Autori principali: Krawczyk, Marcin, Milkiewicz, Malgorzata, Marschall, Hanns-Ulrich, Bartz, Clemens, Grünhage, Frank, Wunsch, Ewa, Milkiewicz, Piotr, Lammert, Frank
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190538/
https://ncbi.nlm.nih.gov/pubmed/25297933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06374
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