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Variant adiponutrin confers genetic protection against cholestatic itch
Lysophosphatidic acid (LPA) mediates cholestatic pruritus. Recently the enzyme PNPLA3, expressed in liver and skin, was demonstrated to metabolise LPA. Here we assess the association of the PNPLA3 variant p.Ile148Met, known to be associated with (non-)alcoholic fatty liver disease (NAFLD) in genome-...
Αποθηκεύτηκε σε:
Κύριοι συγγραφείς: | , , , , , , , |
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Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
Nature Publishing Group
2014
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Θέματα: | |
Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4190538/ https://ncbi.nlm.nih.gov/pubmed/25297933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06374 |
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