Design, Synthesis, and Evaluation of Dasatinib-Amino Acid and Dasatinib-Fatty Acid Conjugates as Protein Tyrosine Kinase Inhibitors

Derivatives of dasatinib were synthesized via esterification with 25 carboxylic acids including amino acids and fatty acids by extending the inhibitor to interact with more diverse sites and to improve specificity. Dasatinib-L-arginine derivative (Das-R, 7) was the most potent of the inhibitors test...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:ChemMedChem
Autores principales: Tiwari, Rakesh K., Brown, Alex, Sadeghiani, Neda, Shirazi, Amir Nasrolahi, Bolton, Jared, Tse, Amanda, Verkhivker, Gennady, Parang, Keykavous, Sun, Gongqin
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224969/
https://ncbi.nlm.nih.gov/pubmed/27875633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201600387
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares