Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED

Polycomb repressive complex 2 (PRC2), a histone H3 lysine 27 methyltransferase, plays a key role in gene regulation and is a known epigenetics drug target for cancer therapy. The WD40 domain-containing protein EED is the regulatory subunit of PRC2. It binds to the tri-methylated lysine 27 of the his...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Li, Ling, Zhang, Hailong, Zhang, Man, Zhao, Mengxi, Feng, Lijian, Luo, Xiao, Gao, Zhenting, Huang, Ying, Ardayfio, Ophelia, Zhang, Ji-Hu, Lin, Ying, Fan, Hong, Mi, Yuan, Li, Guobin, Liu, Lei, Feng, Leying, Luo, Fangjun, Teng, Lin, Qi, Wei, Ottl, Johannes, Lingel, Andreas, Bussiere, Dirksen E., Yu, Zhengtian, Atadja, Peter, Lu, Chris, Li, En, Gu, Justin, Zhao, Kehao
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224880/
https://ncbi.nlm.nih.gov/pubmed/28072869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169855
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados