Discovery, Total Synthesis and Key Structural Elements for the Immunosuppressive Activity of Cocosolide, a Symmetrical Glycosylated Macrolide Dimer from Marine Cyanobacteria

A new dimeric macrolide xylopyranoside, cocosolide (1), was isolated from the marine cyanobacterium preliminarily identified as Symploca sp. from Guam. The structure was determined by a combination of NMR, HRMS, X-ray diffraction studies and Mosher’s analysis of the base hydrolysis product. Its carb...

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Publicado no:Chemistry
Main Authors: Gunasekera, Sarath P., Li, Yang, Ratnayake, Ranjala, Luo, Danmeng, Lo, Jeannette, Reibenspies, Joseph H., Xu, Zhengshuang, Clare-Salzler, Michael J., Ye, Tao, Paul, Valerie J., Luesch, Hendrik
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224530/
https://ncbi.nlm.nih.gov/pubmed/27139508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201600674
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